Scientific Studies

Meal Replacement

Enhanced weight loss with protein-enriched meal replacements in subjects with the metabolic syndrome.Flechtner-Mors M, Boehm BO, Wittmann R, Thoma U, Ditschuneit HH. Diabetes Metab Res Rev. 2010 Jul;26(5):393-405.PMID: 20578205

Protein metabolic roles in treatment of obesity. Devkota S, Layman DK.Curr Opin Clin Nutr Metab Care. 2010 Jul;13(4):403-7.PMID: 20531180

A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adults. Layman DK, Evans EM, Erickson D, Seyler J, Weber J, Bagshaw D, Griel A, Psota T, Kris-Etherton P.J Nutr. 2009 Mar;139(3):514-21. Epub 2009 Jan 21.PMID: 19158228

Maintenance of resting energy expenditure after weight loss in premenopausal women: potential benefits of a high-protein, reduced-calorie diet. Pasiakos SM, Mettel JB, West K, Lofgren IE, Fernandez ML, Koo SI, Rodriguez NR.Metabolism. 2008 Apr;57(4):458-64.PMID:

Weight management using a meal replacement strategy: meta and pooling analysis from six studies.Heymsfield SB, van Mierlo CA, van der Knaap HC, Heo M, Frier. Int J Obes Relat Metab Disord. 2003 May;27(5):537-49.

Efficacy of low-calorie, partial meal replacement diet plans on weight and abdominal fat in obese subjects with metabolic syndrome: a double-blind, randomised controlled trial of two diet plans – one high in protein and one nutritionally balanced. Lee K, Lee J, Bae WK, Choi JK, Kim HJ, Cho B. Int J Clin Pract. 2009 Feb;63(2):195-201. Erratum in: Int J Clin Pract. 2009 May;63(5):829. PMID: 19196357

Meal replacements are as effective as structured weight-loss diets for treating obesity in adults with features of metabolic syndrome. Noakes M, Foster PR, Keogh JB, Clifton PM.  J Nutr. 2004 Aug;134(8):1894-9.PMID: 15284372

Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. McGill AT, Stewart JM, Lithander FE, Strik CM, Poppitt SD. Nutr J. 2008 Jan 28;7:4.PMID: 18226257

Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. St-Onge MP, Jones PJ.  J Nutr. 2002 Mar;132(3):329-32. Review.

The survival advantage of milk and dairy consumption: an overview of evidence from cohort studies of vascular diseases, diabetes and cancer. Elwood PC, Givens DI, Beswick AD, Fehily AM, Pickering JE, Gallacher J. J Am Coll Nutr. 2008 Dec;27(6):723S-34S

Improved nutrient intake in older obese adults undergoing a structured diet and exercise intentional weight loss program. Miller GD. J Nutr Health Aging. 2010 Jun;14(6):461-6

To read more about the dangers of soy and soy products go to  a non-profit health watchdog service


An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. Preuss HG, Rao CV, Garis R, Bramble JD, Ohia SE, Bagchi M, Bagchi D. J Med. 2004;35(1-6):33-48.

Effects of (-)-hydroxycitrate on net fat synthesis as de novo lipogenesis. Kovacs EM, Westerterp-Plantenga MS. Physiol Behav. 2006 Jul 30;88(4-5):371-81. Epub 2006 May 24

Hydroxycitric acid delays intestinal glucose absorption in rats. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, van Dijk TH, Stellaard F, Nieuwenhuizen AG, Verkade HJ, Scheurink AJ. Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1144-9. Epub 2004 Dec 16

Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Shara M, Ohia SE, Schmidt RE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi  M, Chatterjee A, Bagchi D, Stohs SJ.Mol Cell Biochem. 2004 May;260(1-2):171-86.

Hydroxycitrate has long-term effects on feeding behavior, body weight regain and metabolism after body weight loss in male rats. Leonhardt M, Langhans W. J Nutr. 2002 Jul;132(7):1977-82.

Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Preuss HG, Bagchi D, Bagchi M, Rao CV, Dey DK, Satyanarayana S. Diabetes Obes Metab. 2004 May;6(3):171-80.

Comparing metabolic effects of six different commercial trivalent chromium compounds.
Preuss HG, Echard B, Perricone NV, Bagchi D, Yasmin T, Stohs SJ. J Inorg Biochem. 2008 Nov;102(11):1986-90. Epub 2008 Jul 31.

Chromium Effects on Glucose Tolerance and Insulin Sensitivity in People at Risk for Diabetes. Ali A, Ma Y, Reynolds J, Wise JP, Inzucchi SE, Katz DL. Endocr Pract. 2010 Jul 14:1-21

Gymnema sylvestre: A Memoir. Kanetkar P, Singhal R, Kamat M. J Clin Biochem Nutr. 2007 Sep;41(2):77-81.

An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents. Porchezhian E, Dobriyal RM. Pharmazie. 2003 Jan;58(1):5-12

Oolong tea increases metabolic rate and fat oxidation in men. Rumpler W, Seale J, Clevidence B, Judd J, Wiley E, Yamamoto S, Komatsu T, Sawaki T, Ishikura Y, Hosoda K. J Nutr. 2001 Nov;131(11):2848-52

Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Xue WL, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ. Asia Pac J Clin Nutr. 2007;16 Suppl 1:422-6.


n-3 fatty acids and the metabolic syndrome. Carpentier YA, Portois L, Malaisse WJ.Am J Clin Nutr. 2006 Jun;83(6 Suppl):1499S-1504S. Review

Omega-3 fatty acids in inflammation and autoimmune diseases. Simopoulos AP.J Am Coll Nutr. 2002 Dec;21(6):495-505.

n-3 fatty acid supplements in rheumatoid arthritis. Kremer JM.Am J Clin Nutr. 2000 Jan;71(1 Suppl):349S-51S

Dietary supplementation with fish oil in ulcerative colitis. Stenson WF, Cort D, Rodgers J, Burakoff R, DeSchryver-Kecskemeti K, Gramlich TL, Beeken W. Ann Intern Med. 1992 Apr 15;116(8):609-14.

Dietary omega-3 fats for treatment of inflammatory joint disease: efficacy and utility. Proudman SM, Cleland LG, James MJ. Rheum Dis Clin North Am. 2008 May;34(2):469-79

Omega-3 oil intake during weight loss in obese women results in remodelling of plasma triglyceride and fatty acids. McCombie G, Browning LM, Titman CM, Song M, Shockcor J, Jebb SA, Griffin JL.Metabolomics. 2009 Sep;5(3):363-374. Epub 2009 Apr 26.

Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Ebrahimi M, Ghayour-Mobarhan M, Rezaiean S, Hoseini M, Parizade SM, Farhoudi F, Hosseininezhad SJ, Tavallaei S, Vejdani A, Azimi-Nezhad M, Shakeri MT, Rad MA, Mobarra N, Kazemi-Bajestani SM, Ferns GA.Acta Cardiol. 2009 Jun;64(3):321-7


Cornerstone Wellness Technology

Clarification:  Cornerstone partners with the company Stayhealthy, such that studies pertaining to the Cornerstone BC IV are applicable to the Stayhealthy BC 1  and the predecessor to the Cornerstone ACT I was the Stayhealthy RT-3.

The Stayhealthy bioelectrical impedance analyzer predicts body fat in children and adults. Erceg DN, Dieli-Conwright CM, Rossuello AE, Jensky NE, Sun S, Schroeder ET.
Nutr Res. 2010 May;30(5):297-304.

Construct validity of RT3 accelerometer: a comparison of level-ground and treadmill walking at self-selected speeds. Hendrick P, Boyd T, Low O, Takarangi K, Paterson M, Claydon L, Milosavljevic S.J Rehabil Res Dev. 2010;47(2):157-68

Utility of the RT3 triaxial accelerometer in free living: an investigation of adherence and data loss. Perry MA, Hendrick PA, Hale L, Baxter GD, Milosavljevic S, Dean SG, McDonough SM, Hurley DA. Appl Ergon. 2010 May;41(3):469-76. Epub 2009 Oct 29.

Estimating energy expenditure with the RT3 triaxial accelerometer. Maddison R, Jiang Y, Hoorn SV, Mhurchu CN, Lawes CM, Rodgers A, Rush E.Res Q Exerc Sport. 2009 Jun;80(2):249-56.

Comparing the 7-day physical activity recall with a triaxial accelerometer for measuring time in exercise.Sloane R, Snyder DC, Demark-Wahnefried W, Lobach D, Kraus WE. Med Sci Sports Exerc. 2009 Jun;41(6):1334-40