The Cornerstone High Protein Meal Replacement is the highest protein, highest vitamin and mineral, all natural meal replacement on the market today. In addition to being the most nutritious it is widely considered the best tasting and smoothest consistency. It can only be dispensed by medical doctors who practice “medical weight loss” and whose staff been intensively trained by Cornerstone Wellness. It cannot be purchased in stores, on the Internet or from Cornerstone Wellness directly. It is formulated at the second largest supplement manufacturing plant in the US located in Orange County CA, which has been recognized extensively by the FDA’s Good Manufacturing Practices (GMP) program.

The protein mixture in the Cornerstone shake is 95% whey protein concentrate and 5% pea protein. Pea protein will be discussed in a later post. Cow mIlk protein is 20% whey and 80% casein by weight. Interestingly human milk is about 90% whey in the first few days after birth and then reaches 60%. No wonder whey is so highly tolerable by humans Whey is superior to all other protein powders, specifically the 3 other common powdered proteins casein soy and egg.

Whey is superior to all other protein powders for the following reasons.

  • Whey has the highest biological value with regards to digestibility, bioavailability or biological value (BV). The BV for whey is 104, casein is 77, soy is 74, egg is 100 and wheat is 64.
  • Whey has the highest amounts of the branched chain amino acids which are the “muscle building” amino acids leucine, isoleucine and valine. Whey has 11g of leucine whereas casein has only 8g.
  • Whey induces much greater gains in muscle mass than casein (5kg vs 0.8kg) and strength in one study of body builders than casein. In the same study and the whey group lost 1.5kg of fat while the casein group gained 0.2 kg of fat.
Cribb PJ, Williams AD, Carey MF, Hayes A. The effect of whey isolate and resistance training on strength, body composition, and plasma glutamine. Int J Sport Nutr Exerc Metab. 2006;16:494–509.
  • Other studies demonstrating whey concentrate appears to be superior to casein and soy with regards to fat loss, fat oxidation and weight loss as opposed to casein or soy protein.
Bendsten LQ et al1.Effects of hydrolyzed casein, intact casein and intact whey protein on energy expenditure and appetite regulation: a randomised, controlled, cross-over study. .Br J Nutr 2014 Oct 28;112(8):1412-22
Baer DJ et al.Whey protein but not soy protein supplementation alters body weight and composition in free-living overweight and obese adults.J Nutr 2011 Aug;141(8):1489-94.
  • Whey is considered a “fast protein” as it is gets through the stomach faster than casein which curdles (hydrolizes in the stomach acid), but once in the small intestine whey moves through more slowly which means greater and more thorough absorption of its amino acids into the circulation. This is thought to be why whey is great for quick incorporation into muscle after workouts yet also more satiating “appetite controlling” than casein.
Pal SJ et al.Comparative effects of whey and casein proteins on satiety in overweight and obese individuals: a randomized controlled trial. Eur J Clin Nutr 2014 Sep;68(9):980-6.

Veldhorst MA. Dose-dependent satiating effect of whey relative to casein or soy.. Physiol Behav2009 Mar 23;96(4-5):675-82.

  • Milk allergies are almost universally due to casein, never whey, since it is a much smaller molecule than casein. Lactose intolerance is not an allergy but rather a gastrointestinal intolerance to milk sugar or lactose. Some people, primarily of African and Asian descent don’t make enough of the enzyme lactase, which digests lactose, and this can cause diarrhea and hyper-flatulence due to the incomplete digestion. Whey concentrate has very little lactose typically not enough to cause problems except in cases of severe lactose intolerance.
  • Whey protein lowers blood pressure as it has anti-hypertensive compounds called lactokinins that are similar in action to the medications that are ACE inhibitors and one study from Denmark showed less hypertension in milk drinkers.
Yamamoto N Antihypertensive peptides derived from milk protein. Journal of Dairy Science. 1999 June;43(3):159-64.
  • Whey protein has anti diabetic properties, lowering blood sugar by increasing insulin levels and insulin sensitivity.
Pars S, Ellis V The chronic effects of whey proteins on blood pressure, vascular function, and inflammatory markers in overweight individuals. Obesity (Silver Spring). 2010 Jul;18(7):1354-9.
  • Whey protein reduces inflammation, which is a huge risk factor for heart disease and many other diseases. A large review showed significant reduction in CRP (C- reactive protein) with high doses of whey.
Zhou Lm et al. C-reactive protein: a meta-analysis of randomized controlled trials. Nutrients 2015 Feb 9;7(2):1131-43.
  • Whey has been shown in rats and humans to improve permeability and morphology in Crohn’s disease due at least partially to its high glutamine levels.
Benjamin C et al Glutamine and whey protein improve intestinal permeability and morphology in patients with Crohn’s disease: a randomized controlled trial Dig Disease 2012 Apr;57(4):1000-12.
  • Whey protein supplementation may strengthen the body’s antioxidant defenses by promoting the formation of glutathione, one of the body’s main antioxidants. Several studies have shown improvements in fatty liver (NASH) and cancer.
Chitapanarux T et al. Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis (fatty liver) patients.J Gastroenterology Hepatology 2009 Jun;24(6):1045-50..1440-1746.
1.Bounous G Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Research2000 Nov-Dec;20(6C):4785-92.
  • Whey intake significantly reduced post-prandial (post meal) release of chylomicrons (fat globules) compared to casein thereby reducing cardiovascular risk
Bohl M . Dairy proteins, dairy lipids, and postprandial lipemia in persons with abdominal obesity (DairyHealth): a 12-wk, randomized, parallel-controlled, double-blinded, diet intervention study. Am J Cli Nutr 2015 Apr;101(4):870-8.

In conclusion, for the many reasons listed above, whey is superior to casein for those wanting to build or maintain muscle mass while losing fat and looking for satiety to help with calorie restriction. In addition there are several other properties such as anti inflammatory, anti diabetic properties etc in whey that make it perfect for the type of patients we focus on in the Cornerstone Wellness program ie patients with varying degrees of insulin resistance due to excess body fat.